DNA bound proteins such as transcription factors and modified histone proteins
play an important role in gene regulation.
Therefore, their genomic locations are of great interest.
Usually, the location is measured using ChIP-seq and analyzed using a peak-caller.
Replicated ChIP-seq experiments become more and more available.
Sierra Platinum allows
to call peaks for several replicates and also provides a variety of
Together with integrated visualizations, the quality measures
support the assessment of the replicates and the resulting peaks.
Sierra Platinum outperforms other methods.
We here provide Sierra Platinum Service: the first webserver for multi-replicate peak-calling.
- Provide an email-address and start your own Sierra
Platinum server for peak calling. We will notify you by
email once the server is ready to accept your
job. Your server will run 72 hours in
- Download the Sierra client and connect to your Sierra
server (using the provided server settings).
- Upload your data using the client and start peak
calling. You can improve the results by disabling or
downweighting replicates based on the visual quality
- Download your result using the client.